New gene in the homologous human 11q13?q14 and mouse 7F chromosomal regions
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Chromosomal mapping of the tankyrase gene in human and mouse.
Functional gene description: Tankyrase (TNKS) is a ovel gene with homology to both ankyrins and the cataytic domain of poly(ADP-ribose) polymerase (PARP) that as recently cloned using a yeast two-hybrid screen with he telomere-specific DNA binding protein TRF1 (1). ankyrase protein is located at telomeres, centrosomes, nd nuclear pore complexes (1; S. Smith and T. de Lange, n preparation). In v...
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in current study, 63 samples of bat populations collected from differ regions were used for evaluating the geographic variations. twenty cranial and dental characters for traditional morphometric and landmarks method on the ventral, dorsal skull and mandible for geometry morphometric studies were used. statistical analyses of traditional morphometric and geometry morphometric data indicated low...
Chromosomal localization of the human apolipoprotein B gene and detection of homologous RNA in monkey intestine.
A cDNA clone of the human apolipoprotein B-100 was used as a hybridization probe to detect homologous sequences in both flow-sorted and in situ metaphase chromosomes. The results indicate that the gene encoding this protein is on the distal end of the short arm of chromosome 2 (2p23-2p24). RNA isolated from monkey small intestine contained sequences (6.5 and 18 kilobases) homologous to the cDNA...
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The mouse Lyt-1, Lyt-2, and Lyt-3 lymphocyte surface antigens have been used for some years now as immunogenet ic markers whose selective expression distinguishes maturat ional and functional T cell subpopulations (1, 2). Lyt-2 and Lyt-3, for example, are selectively expressed on cytotoxic and suppressor T cells but are not found on helper T cells (3, 4). Similarly, cytotoxic depletion studies ...
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The possibility to reprogram somatic human cells will greatly and deeply change genetic approach and allow the development of new tools to study genetics diseases. Indeed, our ability to study human genetic diseases suffers from the lack of valid in vitro models. The latter should (i) be originating from human primary cells, (ii) be able to self-renew for a long time and (iii) be able to differ...
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ژورنال
عنوان ژورنال: Mammalian Genome
سال: 1992
ISSN: 0938-8990,1432-1777
DOI: 10.1007/bf00302877